|
|
H2O + N8-Acetylspermidine <=> spermidine + acetate
|
3.5.1.48
acetylspermidine deacetylase
|
–
|
|
|
BRENDA:
BR19249
KEGG:
R07300
MetaCyc:
ACETYLSPERMIDINE-DEACETYLASE-RXN
|
|
|
|
glutathionylspermidine + H2O <=> glutathione + spermidine
|
3.5.1
3.5.1.78
glutathionylspermidine amidase
|
–
–
|
K
|
|
BRENDA:
BR3215
KEGG:
R01918
MetaCyc:
GSPAMID-RXN
SABIO-RK:
1972
|
|
|
|
spermidine + H2O + acceptor <=> 1,3-diaminopropane + 4-Aminobutyraldehyde + reduced_acceptor
|
1.4.9.1
methylamine dehydrogenase (amicyanin)
1.5.99.6
spermidine dehydrogenase
|
–
–
|
BK
|
|
BRENDA:
BR36917
KEGG:
R01915
MetaCyc:
SPERMIDINE-DEHYDROGENASE-RXN
SABIO-RK:
1969
|
|
|
|
spermidine + S-adenosylmethioninamine <=> H+ + spermine + S-methyl-5''-thioadenosine
|
2.5.1.104
N1-aminopropylagmatine synthase
2.5.1.16
spermidine synthase
2.5.1.22
spermine synthase
2.5.1.23
sym-norspermidine synthase
2.5.1.79
thermospermine synthase
|
–
–
–
–
–
|
BMK
|
|
BRENDA:
BR44280
KEGG:
R02869
MetaCyc:
SPERMINE-SYNTHASE-RXN
SABIO-RK:
2733
|
|
|
|
spermidine + [eIF5A-precursor]-lysine <=> [eIF5A-precursor]-deoxyhypusine + 1,3-diaminopropane + H+
|
2.5.1.46
deoxyhypusine synthase
|
–
|
|
|
BRENDA:
BR47509
KEGG:
R05329
MetaCyc:
2.5.1.46-RXN
SABIO-RK:
4937
|
|
|
|
spermidine + putrescine <=> Homospermidine + 1,3-diaminopropane
|
2.5.1.44
homospermidine synthase
2.5.1.45
homospermidine synthase (spermidine-specific)
2.5.1.46
deoxyhypusine synthase
|
–
–
–
|
M
|
|
BRENDA:
BR47510
KEGG:
R01919
MetaCyc:
2.5.1.45-RXN
SABIO-RK:
1973
|
|
|
|
putrescine + S-adenosylmethioninamine <=> H+ + spermidine + S-methyl-5''-thioadenosine
|
2.5.1.104
N1-aminopropylagmatine synthase
2.5.1.16
spermidine synthase
2.5.1.23
sym-norspermidine synthase
|
–
–
–
|
BMK
|
|
BRENDA:
BR47664
KEGG:
R01920
MetaCyc:
SPERMIDINESYN-RXN
SABIO-RK:
1974
|
|
|
|
S-adenosylmethioninamine + spermidine <=> S-methyl-5''-thioadenosine + thermospermine + H+
|
2.5.1.126
norspermine synthase
2.5.1.127
caldopentamine synthase
2.5.1.23
sym-norspermidine synthase
2.5.1.79
thermospermine synthase
|
–
–
–
–
|
|
|
BRENDA:
BR48988
KEGG:
R09531
MetaCyc:
RXN-11190
|
|
|
|
spermine + O2 + H2O <=> spermidine + 3-aminopropionaldehyde + H2O2
|
1.5.3.16
spermine oxidase
1.5.3.17
non-specific polyamine oxidase
|
–
–
|
BMK
|
|
BRENDA:
BR48997
KEGG:
R09076
MetaCyc:
RXN-9015
SABIO-RK:
7728
|
|
|
|
spermidine + O2 + H2O <=> putrescine + 3-aminopropionaldehyde + H2O2
|
1.5.3.16
spermine oxidase
1.5.3.17
non-specific polyamine oxidase
|
–
–
|
MK
|
|
BRENDA:
BR49070
KEGG:
R09077
MetaCyc:
RXN-12089
SABIO-RK:
7730
|
|
|
|
N1-acetylspermine + O2 + H2O <=> spermidine + 3-acetamidopropanal + H2O2
|
1.5.3.13
N1-acetylpolyamine oxidase
1.5.3.16
spermine oxidase
1.5.3.17
non-specific polyamine oxidase
|
–
–
–
|
M
|
|
BRENDA:
BR49071
KEGG:
R03899
MetaCyc:
RXN-12090;
RXN-9940
SABIO-RK:
13417
|
|
|
|
spermidine + O2 + H2O <=> 1,3-diaminopropane + 4-Aminobutyraldehyde + H2O2
|
1.4.3.10
putrescine oxidase
1.5.3.14
polyamine oxidase (propane-1,3-diamine-forming)
1.5.99.6
spermidine dehydrogenase
|
–
–
–
|
MK
|
|
BRENDA:
BR49074
KEGG:
R01914
MetaCyc:
RXN-10747
SABIO-RK:
1968
|
|
|
|
carboxyspermidine + H+ <=> spermidine + CO2
|
4.1.1
4.1.1.96
carboxynorspermidine decarboxylase
|
–
–
|
BMK
|
|
BRENDA:
BR50202
KEGG:
R09081
MetaCyc:
RXN-11564
|
|
|
|
N1-aminopropylagmatine + H2O <=> spermidine + Urea
|
3.5.3.24
N1-aminopropylagmatine ureohydrolase
|
–
|
BM
|
|
BRENDA:
BR50461
KEGG:
R10347
MetaCyc:
RXN-12515
|
|
|
|
spermidine + NAD+ <=> dehydrospermidine + NADH + H+
|
2.5.1.46
deoxyhypusine synthase
|
–
|
M
|
|
BRENDA:
BR50491
KEGG:
R07477
MetaCyc:
RXN-13414
|
|
|
|
S-adenosylmethioninamine + spermidine <=> S-methyl-5''-thioadenosine + N4-bis(aminopropyl)spermidine + H+
|
2.5.1.128
N4-bis(aminopropyl)spermidine synthase
|
–
|
|
|
BRENDA:
BR51123
KEGG:
R11154
MetaCyc:
RXN-15866
|
|
|
|
S-adenosylmethioninamine + spermidine <=> S-methyl-5''-thioadenosine + N4-aminopropylspermidine + H+
|
2.5.1.128
N4-bis(aminopropyl)spermidine synthase
|
–
|
BM
|
|
BRENDA:
BR51124
KEGG:
R11159
MetaCyc:
RXN-15864
|
|
|
|
sinapoyl-CoA + spermidine <=> CoA + N1,N8-bis(sinapoyl)-spermidine + H+
|
2.3.1.248
spermidine disinapoyl transferase
|
–
|
|
|
BRENDA:
BR51400
KEGG:
R11199
MetaCyc:
RXN-16472
|
|
|
|
4-coumaroyl-CoA + spermidine <=> CoA + N1,N8-bis(4-coumaroyl)-spermidine + H+
|
2.3.1.249
spermidine dicoumaroyl transferase
|
–
|
|
|
BRENDA:
BR51401
KEGG:
R11200
MetaCyc:
RXN-16473
|
|
|
|
spermidine + glutathione + ATP <=> H+ + glutathionylspermidine + ADP + phosphate
|
6.3.1.8
glutathionylspermidine synthase
6.3.1.9
trypanothione synthase
|
–
–
|
BMK
|
|
BRENDA:
BR99
KEGG:
R01917
MetaCyc:
GSPSYN-RXN
SABIO-RK:
1971
|
|
|
|
ATP + spermidine + H2O <=> ADP + phosphate + spermidine + H+
|
7.6.2.11
ABC-type polyamine transporter
|
–
|
|
|
BRENDA:
BS141432
MetaCyc:
ABC-24-RXN
|
|
|
|
acetyl-CoA + spermidine <=> N1-acetylspermidine + H+ + CoA
|
2.3.1.57
diamine N-acetyltransferase
|
–
|
BM
|
|
BRENDA:
BS321083
MetaCyc:
SPERMACTRAN-RXN
SABIO-RK:
7731
|
|
|
|
N1-(3,4-Dihydroxybenzoyl)-N8-citryl_spermidine + spermidine + ATP <=> H+ + N1-(3,4-dihydroxybenzoyl)-N8,N''8-citryl-bis(spermidine) + AMP + diphosphate
|
6.3.2
|
–
|
MK
|
|
KEGG:
R12599
MetaCyc:
RXN-10678
|
|
|
|
spermidine + citrate + ATP <=> H+ + N-Citryl-spermidine + AMP + diphosphate
|
6.3.2
|
–
|
MK
|
|
KEGG:
R12596
MetaCyc:
RXN-10680
|
|
|
|
N-Citryl-spermidine + spermidine + ATP <=> H+ + N8,N''8-citryl-bis(spermidine) + AMP + diphosphate
|
6.3.2
|
–
|
MK
|
|
KEGG:
R12598
MetaCyc:
RXN-10681
|
|
|
|
4-coumaroyl-CoA + spermidine <=> N1,N5,N10-Tricoumaroyl_spermidine + CoA + H+
|
2.3.1.M34
|
–
|
MK
|
|
KEGG:
R08983
MetaCyc:
RXN-11257
|
|
|
|
Carbamoyl_phosphate + spermidine <=> phosphate + N-carbamoylspermidine
|
2.1.3.6
putrescine carbamoyltransferase
|
–
|
|
|
BRENDA:
BS320110
SABIO-RK:
11271
|
|
|
|
caffeoyl-CoA + spermidine <=> CoA + N1,N5,N10-Tricaffeoyl_spermidine + H+
|
2.3.1.M34
|
–
|
M
|
|
MetaCyc:
RXN-11258
|
|
|
|
feruloyl-CoA + spermidine <=> CoA + N1,N5,N10-Triferuloyl_spermidine + H+
|
2.3.1.M34
|
–
|
M
|
|
MetaCyc:
RXN-11259
|
|
|
|
acetyl-CoA + spermidine <=> N8-Acetylspermidine + H+ + CoA
|
2.3.1.57
diamine N-acetyltransferase
|
–
|
|
|
MetaCyc:
RXN0-7165
|
|
|
|
H+ + spermidine <=> H+ + spermidine
|
not assigned
|
–
|
|
|
MetaCyc:
TRANS-RXN0-266
|
|
|
|
spermine + ferricyanide <=> spermidine + 3-aminopropionaldehyde + ferrocyanide
|
1.5.99.6
spermidine dehydrogenase
|
–
|
|
|
BRENDA:
BS389781
|
|
|
|
N1-acetylspermine + O2 + H2O <=> spermidine + acetaminopropanal+_H2O2
|
1.5.3.16
spermine oxidase
1.5.3.17
non-specific polyamine oxidase
|
–
–
|
|
|
BRENDA:
BS415003
|
|
|
|
spermidine + cadaverine <=> N-(4-aminobutyl)-1,5-diaminopentane + Homospermidine + 1,3-diaminopropane + putrescine
|
2.5.1.44
homospermidine synthase
|
–
|
|
|
BRENDA:
BS437907
|
|
|
|
spermidine <=> Homospermidine + putrescine + 1,3-diaminopropane
|
2.5.1.44
homospermidine synthase
|
–
|
|
|
BRENDA:
BS189566
|
|
|
|
spermidine + putrescine <=> Homospermidine + 1,3-diaminopropane + putrescine
|
2.5.1.44
homospermidine synthase
|
–
|
|
|
BRENDA:
BS437908
|
|
|
|
putrescine + 1,3-diaminopropane <=> Homospermidine + spermidine
|
2.5.1.44
homospermidine synthase
|
–
|
|
|
BRENDA:
BS189567
|
|
|
|
spermine + 2,6-dichlorophenolindophenol <=> spermidine + 3-aminopropionaldehyde + reduced_2,6-dichlorophenolindophenol
|
1.5.99.6
spermidine dehydrogenase
|
–
|
|
|
BRENDA:
BS389780
|
|
|
|
spermidine + O2 + H2O <=> N,N''-bis(3-aminopropyl)-4-aminobutanal + NH3 + H2O2
|
1.4.3.10
putrescine oxidase
|
–
|
|
|
BRENDA:
BS427062
|
|
|
|
spermidine + H2O + O2 <=> 1,3-diaminopropane + NH3 + H2O2
|
1.4.3.22
diamine oxidase
|
–
|
|
|
BRENDA:
BS441984
|
|
|
|
spermine + phenazine_methosulfate <=> spermidine + 3-aminopropionaldehyde + reduced_phenazine_methosulfate
|
1.5.99.6
spermidine dehydrogenase
|
–
|
|
|
BRENDA:
BS389783
|
|
|
|
N1-(3-benzylaminopropyl)butane-1,4-diamine + O2 + H2O <=> spermidine + H2O2 + benzyl_alcohol
|
1.5.3.13
N1-acetylpolyamine oxidase
|
–
|
|
|
BRENDA:
BS426762
|
|
|
|
N1-monoethylspermine + O2 + H2O <=> spermidine + N-ethyl-3-aminopropanal + H2O2
|
1.5.3.16
spermine oxidase
|
–
|
|
|
BRENDA:
BS426764
|
|
|
|
spermine + O2 + H2O <=> spermidine + 1,3-diaminopropane + H2O2
|
1.5.3.14
polyamine oxidase (propane-1,3-diamine-forming)
|
–
|
|
|
BRENDA:
BS410311
|
|
|
|
spermidine + O2 + H2O <=> putrescine + 3-aminobutanal + H2O2
|
1.5.3.17
non-specific polyamine oxidase
|
–
|
|
|
BRENDA:
BS425035
|
|
|
|
spermidine + 2,6-dichlorophenolindophenol <=> 1,3-diaminopropane + 4-Aminobutyraldehyde + reduced_2,6-dichlorophenolindophenol
|
1.5.99.6
spermidine dehydrogenase
|
–
|
|
|
BRENDA:
BS389776
|
|
|
|
spermidine + 2,6-dichlorophenolindophenol <=> 1,3-diaminopropane + DELTA1-pyrroline + reduced_2,6-dichlorophenolindophenol
|
1.5.99.6
spermidine dehydrogenase
|
–
|
|
|
BRENDA:
BS259406
|
|
|
|
spermidine + ferricyanide <=> 1,3-diaminopropane + 4-Aminobutyraldehyde + ferrocyanide
|
1.5.99.6
spermidine dehydrogenase
|
–
|
|
|
BRENDA:
BS389777
|
|
|
|
spermidine + K3Fe(CN)6 <=> 1,3-diaminopropane + DELTA1-pyrroline + ferrocyanide
|
1.5.99.6
spermidine dehydrogenase
|
–
|
|
|
BRENDA:
BS259404
|
|
|
|
spermidine + cadaverine <=> Homospermidine + N-(4-aminobutyl)-1,5-diaminopentane
|
2.5.1.44
homospermidine synthase
|
–
|
|
|
BRENDA:
BS189572
|
|
|
|
spermidine + 1,6-diaminohexane <=> Homospermidine + N-(4-aminobutyl)-1,6-diaminohexane
|
2.5.1.44
homospermidine synthase
|
–
|
|
|
BRENDA:
BS189573
|
|
|
|
3 acetyl-CoA + spermidine <=> 3 CoA + N1,N4,N8-triacetylspermidine
|
2.3.1.57
diamine N-acetyltransferase
|
–
|
|
|
BRENDA:
BS419940
|
|
|
|
acetyl-CoA + spermidine <=> CoA + N1-acetyl-sym-norspermidine
|
2.3.1.57
diamine N-acetyltransferase
|
–
|
|
|
BRENDA:
BS408306
|
|
|
|
spermidine + GTP + H2O <=> spermidine + GDP + phosphate
|
7.6.2.11
ABC-type polyamine transporter
|
–
|
|
|
BRENDA:
BS141433
|
|
|
|
glutathione + spermidine + MgATP2- <=> glutathionylspermidine + MgADP- + phosphate
|
6.3.1.8
glutathionylspermidine synthase
|
–
|
|
|
BRENDA:
BS369024
|
|
|
|
N1-acetylspermidine + H2O <=> acetate + spermidine
|
3.5.1.4
amidase
3.5.1.48
acetylspermidine deacetylase
3.5.1.62
acetylputrescine deacetylase
|
–
–
–
|
|
|
BRENDA:
BS116338
|
|
|
|
N1,N8-diacetylspermidine + H2O <=> acetate + spermidine
|
3.5.1.48
acetylspermidine deacetylase
|
–
|
|
|
BRENDA:
BS116337
|
|
|
|
spermidine + CTP + H2O <=> spermidine + CDP + phosphate
|
7.6.2.11
ABC-type polyamine transporter
|
–
|
|
|
BRENDA:
BS141435
|
|
|
|
spermidine + electron_acceptor <=> 1,3-diaminopropane + DELTA1-pyrroline + reduced_electron_acceptor
|
1.5.99.6
spermidine dehydrogenase
|
–
|
|
|
BRENDA:
BS259403
|
|
|
|
spermidine <=> 1,3-diaminopropane + DELTA1-pyrroline
|
2.5.1.46
deoxyhypusine synthase
|
–
|
|
|
BRENDA:
BS354964
|
|
|
|
[eIF5A-precursor]-L-lysine + spermidine <=> [eIF5A-precursor]-deoxyhypusine + 1,3-diaminopropane
|
2.5.1.46
deoxyhypusine synthase
|
–
|
|
|
BRENDA:
BS452205
|
|
|
|
[TveIF-5A-precursor]-lysine + spermidine <=> [TveIF-5A-precursor]-deoxyhypusine + 1,3-diaminopropane
|
2.5.1.46
deoxyhypusine synthase
|
–
|
|
|
BRENDA:
BS436581
|
|
|
|
spermidine + phenazine_methosulfate <=> 1,3-diaminopropane + 4-Aminobutyraldehyde + reduced_phenazine_methosulfate
|
1.5.99.6
spermidine dehydrogenase
|
–
|
|
|
BRENDA:
BS389779
|
|
|
|
spermidine + phenazine_methosulfate <=> 1,3-diaminopropane + DELTA1-pyrroline + reduced_phenazine_methosulfate
|
1.5.99.6
spermidine dehydrogenase
|
–
|
|
|
BRENDA:
BS259405
|
|
|
|
spermidine-ubiquitin + H2O <=> ubiquitin + spermidine
|
3.4.19.12
ubiquitinyl hydrolase 1
|
–
|
|
|
BRENDA:
BS36816
|
|
|
|
spermidine + UTP + H2O <=> spermidine + UDP + phosphate
|
7.6.2.11
ABC-type polyamine transporter
|
–
|
|
|
BRENDA:
BS141436
|
|
|
|
gamma-Glu-2-aminobutanoyl-Gly + spermidine + ATP <=> N1-(gamma-L-Glu-L-alpha-aminobutyryl-Gly)-spermidine
|
6.3.1.8
glutathionylspermidine synthase
|
–
|
|
|
BRENDA:
BS393
|
|
|
|
L-gamma-glutamylspermidine <=> spermidine + 5-oxoproline
|
4.3.2.8
gamma-glutamylamine cyclotransferase
|
–
|
|
|
BRENDA:
BS441512
|
|
|
|
spermidine + cytochrome_c <=> 1,3-diaminopropane + 4-Aminobutyraldehyde
|
1.5.99.6
spermidine dehydrogenase
|
–
|
|
|
BRENDA:
BS370180
|
|
|
|
2 glutathione + spermidine + 2 ATP <=> trypanothione + 2 ADP + 2 phosphate
|
6.3.1.8
glutathionylspermidine synthase
6.3.1.9
trypanothione synthase
|
–
–
|
|
|
BRENDA:
BS378685
|
|
|
|
ATP + H2O + spermidine-[polyamine-binding_protein][side_1] <=> ADP + phosphate + spermidine + [polyamine-binding_protein][side_1]
|
7.6.2.11
ABC-type polyamine transporter
|
–
|
|
|
BRENDA:
BS447112
|
|
|
|
ATP + H2O + spermidine-[spermidine-binding_protein][side_1] <=> ADP + phosphate + spermidine + [spermidine-binding_protein][side_1]
|
7.6.2.16
ABC-type putrescine transporter
|
–
|
|
|
BRENDA:
BS448465
|
|
|
|
glutathione + spermidine + ATP <=> glutathionylspermidine + N8-glutathionylspermidine + ADP + phosphate
|
6.3.1.9
trypanothione synthase
|
–
|
|
|
BRENDA:
BS427453
|
|
|
|
5-L-glutamyl-Gly-Gly + spermidine + ATP <=> N1-(gamma-Glu-Gly-Gly)-spermidine + ADP + phosphate
|
6.3.1.8
glutathionylspermidine synthase
|
–
|
|
|
BRENDA:
BS389
|
|
|
|
gamma-Glu-L-Cys(S-butyl)-Gly + spermidine + ATP <=> N1-(gamma-Glu-L-Cys(S-butyl)-Gly)-spermidine + ADP + phosphate
|
6.3.1.8
glutathionylspermidine synthase
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–
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BRENDA:
BS387
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gamma-Glu-L-Cys(S-ethyl)-Gly + spermidine + ATP <=> N1-(gamma-Glu-L-Cys(S-ethyl)-Gly)-spermidine + ADP + phosphate
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6.3.1.8
glutathionylspermidine synthase
|
–
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BRENDA:
BS385
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gamma-Glu-L-Cys(S-propyl)-Gly + spermidine + ATP <=> N1-(gamma-Glu-L-Cys(S-propyl)-Gly)-spermidine + ADP + phosphate
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6.3.1.8
glutathionylspermidine synthase
|
–
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BRENDA:
BS386
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gamma-L-Glu-L-Ser-Gly + spermidine + ATP <=> N1-(gamma-Glu-L-Ser-Gly)-spermidine + ADP + phosphate
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6.3.1.8
glutathionylspermidine synthase
|
–
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BRENDA:
BS388
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gamma-L-Glu-L-Ala-Gly + spermidine + ATP <=> N1-(gamma-L-Glu-L-Ala-Gly)-spermidine + ADP + phosphate
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6.3.1.8
glutathionylspermidine synthase
|
–
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|
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BRENDA:
BS390
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S-Methylglutathione + spermidine + ATP <=> N1-(gamma-L-Glu-L-Cys(S-methyl)-Gly)-spermidine + ADP + phosphate
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6.3.1.8
glutathionylspermidine synthase
|
–
|
|
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BRENDA:
BS384
|
|
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gamma-L-Glu-L-Ile-Gly + spermidine + ATP <=> N1-(gamma-L-Glu-L-Ile-Gly)-spermidine + ADP + phosphate
|
6.3.1.8
glutathionylspermidine synthase
|
–
|
|
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BRENDA:
BS392
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gamma-L-Glu-L-Val-Gly + spermidine + ATP <=> N1-(gamma-L-Glu-L-Val-Gly)-spermidine + ADP + phosphate
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6.3.1.8
glutathionylspermidine synthase
|
–
|
|
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BRENDA:
BS391
|
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spermidine + L-glutamine <=> bis-(glutamyl)-spermidine
|
2.3.2.13
protein-glutamine gamma-glutamyltransferase
|
–
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BRENDA:
BS377778
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